Studies and Projects

The named studies, trials and projects we run

This page lists the individual studies, cohorts, trials and innovation projects hosted at Mildmay Research Centre Uganda (MRCU). For the thematic areas and wider research programme that these projects sit within, see Research.

Clinical studies, trials and cohorts

Current and recent clinical research platforms

Interventional and observational studies conducted in a research environment supported by Mildmay Uganda Hospital.

EDCTP · Phase III trial

PREGART

A randomized non-inferiority clinical trial evaluating the safety and efficacy of dolutegravir and EFV400 in pregnant and breastfeeding women, generating evidence-based recommendations for safe first-line ART regimens in PMTCT.

THRIVE and ViiV Healthcare

UPART

Long-term outcomes of dolutegravir among children and adolescents living with HIV in Uganda, including the use of point-of-care HIV viral load monitoring to improve viral load suppression in this age group.

NIH / NICHD · Randomized trial

GOALS

Goals for Adherence with Low-cost Incentives: a randomized controlled trial evaluating the impact of small airtime incentives on ART adherence among young people living with HIV in Kampala, using behavioural economics.

Pilot randomized trial

INMIND

Incentives and Reminders to Improve Long-term Medication Adherence: structured incentive and reminder models designed to support durable medication adherence behaviours.

Palliative care

GHAP

Piloting Children's Palliative Outcome Scale (C-POS) tools in paediatric life-threatening illness care to improve patient-centred outcome measurement.

Immunology

AMBER

AntiMicrobial B cell Exploratory Research: B-cell immunology and microbiome interactions in infectious and non-communicable diseases affecting maternal and child health, led by Dr. Ramapraba Appanna.

Nationale Postcode Loterij

AIR TBC

Development and evaluation of an AI-powered tuberculosis screening tool.

Implementation and public health projects

Funded implementation and health systems projects

Competitively funded projects supported by leading international research funders and implementation partners.

NIH / NIMH

Depression Care and PMTCT

Generating a model for integrating depression care into antenatal clinics to promote adherence to the PMTCT continuum and improve maternal and child health outcomes.

NIH

Gender-Transformative HIV Care

Developing and evaluating an innovative gender-transformative implementation strategy to improve HIV provider capacity for equitable HIV care in Uganda.

ViiV / GSK

Pediatric Breakthrough Partnership

Implementation research to understand the impact and effectiveness of the Pediatric Breakthrough Partnership across Mozambique, Nigeria and Uganda.

PEPFAR / CDC

Epidemic Control Project

A five-year epidemic control programme across eight districts of the Mubende region that generated longitudinal datasets which continue to inform community health programming.

Unitaid and FIND

PAHLCA-IRI

Comprehensive HIV programming delivered through a multi-principal-investigator consortium.

PENTA Foundation

PENTA / THRIVE

Multi-site paediatric HIV research, with MRCU participating as a satellite site.

Collaboration

Looking for a study partner, site or implementation team?

MRCU hosts clinical trials, implementation research, cohort studies and innovation projects across HIV, TB, maternal health, mental health and digital health.

Discuss a project